Aluminium hydroxyphosphate Adju-Phos
Adju-Phos is a range of aluminium phosphate gel products which have been specifically developed for use as an adjuvant in vaccines. The gel is a suspension of hydrated amorphous aluminium hydroxyphosphate nano/micron size crystal in loose aggregates. Adju-Phos products have a net negative charge at neutral pH and effectively adsorb positively charged antigens. The primary purpose of the adjuvant in vaccines is to boost the antibody-mediated (Th2) immune response to the antigens. Adju-Phos products can be combined with other adjuvant types (such as monophosphoryl lipids) to achieve a balanced Th1/Th2 immune response. Adju-Phos is supplied in two variants with pH-values at ca. 6.5 and at ca. 5.0. Both variants contain 0.9% NaCl (saline) to reduce injection site discomfort. Adju-Phos is produced in classified clean rooms to prevent contamination, sterilised and aseptically filled in a grade A clean room.